The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2SARS-CoV-2에 결합하는 수렴형 IGHV3-53/3-66 항체에 대한 CDR1 체세포 과돌연변이의 두드러진 역할Article Published on 2022-12-012022-09-12 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome Analysis antibodies antibody antibody affinity binding binding affinity Cdr1 contributed Coronavirus-2 COVID-19 Frequency functional germline gene Humoral immunity IGHV3-53/3-66 knowledge mAb mAbs monoclonal monoclonal antibody Mutation other coronaviruses SARS-CoV-2 somatic hypermutation. somatic hypermutations Treatment [DOI] 10.1080/22221751.2022.2063074 PMC 바로가기 [Article Type] Article
Fate of SARS-CoV-2 coronavirus in wastewater treatment sludge during storage and thermophilic anaerobic digestionArticle Published on 2022-11-012022-11-15 Journal: Environmental research [Category] SARS, 치료기술, [키워드] addition ambient anaerobic Bovine coronavirus conducted COVID-19 outbreak Detection limit digestion droplet droplet digital PCR Final inactivated knowledge Laboratory Max 6) other coronaviruses Particle PCR question raised reported RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 coronavirus SARS-CoV-2 detection SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 stability Sludge Stability. Stool stools temperature Treatment virus were used [DOI] 10.1016/j.envres.2022.114057 PMC 바로가기
Accessible and Adaptable Multiplexed Real-Time PCR Approaches to Identify SARS-CoV-2 Variants of ConcernArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome approach collected concern coronavirus COVID-19 COVID-19 pandemic Critical cross-reactivity Delta delta variant detect different time points equipment exhibited FIVE genotyping identify Laboratory lack Limits of detection management melting curve analysis Molecular assay multiplex Multiplex PCR Mutation mutations nine omicron Omicron variant other coronaviruses PCR PCR assay performed platform positive sample Rapid rapid genotyping. Real-time PCR resource RNA SARS-CoV-2 SARS-CoV-2 VOCs selected sensitivity Sequencing signature specificity Spike protein Support Surveillance variant variants variants of concern VoC VOCs WGS [DOI] 10.1128/spectrum.03222-22 PMC 바로가기
SARS-CoV-2 Papain-Like Protease: Structure, Function and InhibitionArticle Published on 2022-10-062022-11-15 Journal: Chembiochem [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] antiviral agent antiviral immune response antivirals coronavirus COVID-19 derivatives Epidemic function Host immune response immune immune response in viral inhibition involved ISG15 less MERS-CoV motif other coronaviruses Papain-like protease posttranslational modifications protease protease inhibitors protease inhibitors. Replication SARS-CoV-1 SARS-CoV-2 Structure targets variants of concern variants of SARS-CoV-2 Viral protein [DOI] 10.1002/cbic.202200327 PMC 바로가기
Neurological Complications in Children Hospitalized With Seizures and Respiratory Infections: A Comparison Between SARS-CoV-2 and Other Respiratory InfectionsArticle Published on 2022-10-012023-07-10 Journal: Pediatric neurology [Category] COVID19(2023년), [키워드] COVID-19 Influenza other coronaviruses parainfluenza pediatric respiratory viruses SARS-CoV-2 Stroke. [DOI] 10.1016/j.pediatrneurol.2022.07.010 PMC 바로가기
Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based InhibitorArticle Published on 2022-09-182022-11-15 Journal: Viruses [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Analysis Antiviral antivirals Basis binding caused consequence coronavirus Coronavirus-2 Coronaviruses COVID-19 crystal structure defined determinant effective effective inhibitor enzyme Health inhibition inhibitor M pro main protease maturation mechanism MERS-CoV molecular other coronaviruses promote protease provide required SARS-CoV SARS-CoV-2 Spread Treatment unique Vaccine variant viral replication warhead. YH-53 [DOI] 10.3390/v14092075 PMC 바로가기
Structural investigations of proteins encoded by SARS-CoV-2Article Published on 2022-09-012022-11-16 Journal: FEBS Open Bio [Category] SARS, 변종, 유전자 메커니즘, [키워드] antibodies articles bases categories cellular cleaved commenced coronavirus COVID COVID-19 pandemic cysteine proteases described ENCODE Evolution example expressed Final Genome include knowledge MN908947.3 molecular mechanism other coronaviruses pandemic polyprotein positive-sense Protein protein structure purified reported Research ribonuclease RNA genome RNAs SARS-CoV-2 selected sequenced single-stranded small molecule drugs Spike protein spike protein. structural property the disease the spike protein translation Vaccines variant viral transcript were expressed [DOI] 10.1002/2211-5463.13465 PMC 바로가기
Contrasting Patterns in the Early Stage of SARS-CoV-2 Evolution between Humans and MinksArticle Published on 2022-09-012022-11-16 Journal: Molecular Biology and Evolution [Category] SARS, 변종, [키워드] adaptive amino acid changes analyzed change circulating deviate domain early phase Epidemic Epidemics Evolution feature Frequency Genetic genetic hitchhiking Host Human humans Infection Ka/Ks lack late phase mink Mutation mutations Neutral nonsynonymous other coronaviruses outbreak pandemic parental pattern positive Positive selection produced receptor-binding motif SARS-CoV SARS-CoV-2 selection process sequence site frequency spectrum site frequency spectrum. Stage Strong synonymous the SARS-CoV-2 the spike protein unique variant virus virus [DOI] 10.1093/molbev/msac156 PMC 바로가기
The molecular epidemiology of multiple zoonotic origins of SARS-CoV-2SARS-CoV-2의 다중 인수공통 기원의 분자 역학Article Published on 2022-08-262022-09-11 Journal: Science (New York, N.y.) [Category] COVID19(2023년), SARS, 유전자 메커니즘, 조류인플루엔자, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cross-species transmission Epidemic event events genomic Human humans involved Lineage Molecular epidemiology occurred other coronaviruses pandemic Pandemics reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus understanding unlikely viral lineages virus zoonotic zoonotic origin zoonotic transmission [DOI] 10.1126/science.abp8337 PMC 바로가기 [Article Type] Article
Heterologous immunity induced by 1st generation COVID-19 vaccines and its role in developing a pan-coronavirus vaccineArticle Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive addition COVID-19 COVID-19 pandemic COVID-19 vaccine cross-reactive develop Evolution Heterologous heterologous immunity highlight Hospitalization illnesses Immunity immunization individual Infection mechanism Mortality MOST mutated mutated variant other coronaviruses pan-coronavirus vaccine pandemic Prevent PROTECT protective role Protein SARS-CoV-2 SARS-CoV-2 antigens T cell the Spike understanding universal vaccine development. Vaccine Vaccine development variant viral strains virulent virus strain [DOI] 10.3389/fimmu.2022.952229 PMC 바로가기